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Hartage Report

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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

Abstract There is an urgent need for antiviral agents that treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs against OC43, a human beta coronavirus that causes the common cold, and evaluated the top hits against SARS-CoV-2. Twenty drugs significantly inhibited…